Gladstone Institutes & UCSF
Join the lab
The Shipman Lab is an inclusive group, open to all scientists.
Graduate Students
Seth is a core member of the Bioengineering, Neuroscience, and Biomedical Sciences graduate programs. If you are interested in a rotation, please email seth.shipman@gladstone.ucsf.edu.
Scientist/Project Manager (PhD and 3+ years postdoc or professional experience)
We are seeking a Scientist / Project Manager to join an exciting project at the interface of two labs in the Gladstone Institutes. The Shipman and Ramani labs develop molecular technology and apply it to understand human genomics in health and disease. As part of a newly created Keck Center for Machine Guided Functional Genomics, we are launching a major endeavor to understand how noncoding variants contribute to cell phenotypes and disease. We are looking for a person to support the experimental components of this ambitious project, which will include high-throughput genome editing and characterization of transcriptional and structural outcomes in cells using innovative sequencing techniques.
A successful candidate needs to be able to contribute to project management focused on achieving milestones in genomic medicine, and a willingness to work on a team-based project at the interface of high-throughput single-molecule genome sequencing, genome editing, and computational genomic tool development. Rigorous scientific standards and exacting organization are critical.
Considering applicants on an ongoing basis.
To apply, send a cover letter and CV to sue.cammack@gladstone.ucsf.edu with the subject line “Application for Keck Scientist Position.”
Qualifications
PhD and 3+ years postdoc or professional experience
Expertise in molecular biotechnology and high-throughput experimentation, with demonstrated track record of success
Experience managing teams and budgets
Lab Manager (open to recent/upcoming graduates with a B.A., B.S., A.A., or A.S.)
The Shipman Lab at the Gladstone Institutes is seeking a highly organized and personable Lab Manager to join our team. We are a vibrant molecular biology lab with twelve members (postbacc, PhD, and postdoc scientists). Our mission is to engineer new biotechnology to overcome challenges in the understanding and treatment of human disease.
The Lab Manager in this position will be responsible for ensuring continuous operations of the lab. General duties include ordering and organization of supplies and reagents, keeping equipment in operation, assisting with the onboarding and offboarding of lab members, and keeping the lab in compliance with safety standards. Additionally, this Lab Manager is expected to become familiar with our most important experimental workflows (e.g. sequencing, cloning, gene editing, strain propagation), so that they can help propel ongoing research forward and transfer accumulated technical knowledge to incoming lab members.
Open to applicants who could start immediately, but also considering applicants who could start May 2024.
To apply, send a cover letter and resume to seth.shipman@gladstone.ucsf.edu.
Qualifications
Undergraduate degree (B.A., B.S. A.A., A.S.), preferentially in Biochemistry, Bioengineering, Chemical Engineering or a related field
Wet Lab experience
Excellent teamwork, organizational, communication, and time-management skills
Research Associate – Shipman Lab (now recruiting for RAs to start summer 2024)
The Shipman Lab at the Gladstone Institutes is seeking an enthusiastic Research Associate to join our team. We develop molecular biotechnology to overcome challenges in the understanding and treatment of human disease. Ongoing projects include therapeutic and multiplexed genome engineering, biological event recording into DNA, mitochondrial transplantation, and phage therapeutics.
The Research Associate in this position will contribute to projects that use biochemistry/molecular biology (cloning, RNA in vitro transcription, and protein expression/purification), cell culture (cell lines, human stem cells, transfection, virus production), structural biology, and bioinformatics. They will also assist in general upkeep of the laboratory such as ordering and organization of supplies and reagents and keeping equipment in operation. The Research Associate will be a full member of the scientific community in the lab, with the expectation that they will develop independent experiments and report results in publications. This would be an excellent opportunity for any candidate who wishes to pursue graduate school in the future.
Open to applicants who could start immediately, but primarily considering applicants who could start ~June 2024.
To apply, send a cover letter and resume to seth.shipman@gladstone.ucsf.edu.
Qualifications
Undergraduate degree in Biochemistry, Bioengineering, Chemical Engineering or related field
1+ years wet lab experience (in addition to lab coursework)
Excellent teamwork, organizational, communication, and time-management skills
Prior experience with mammalian cell culture, bioinformatics, RNA biology, or protein purification ideal
Postdoctoral Scholar – Shipman Lab
The Shipman Lab at the Gladstone Institutes is seeking Postdocs to join our dynamic team. We develop molecular biotechnology to overcome challenges in the understanding and treatment of human disease. Ongoing projects include therapeutic and multiplexed genome engineering, biological event recording into DNA, mitochondrial transplantation, and phage therapeutics. Candidates interested in pursuing translational opportunities and founding companies are encouraged, as are those interested in pursuing academic careers. Postdocs will be trained for scientific leadership, so candidates should be interested in honing mentorship, team building, and project management skills.
Current areas of interest (exciting project ideas outside of these areas also welcomed):
Development of platform technologies for genomic medicine. These technologies should enable precise therapeutic editing, cell engineering, and disease mechanism discovery.
Development and deployment of technologies for phage therapeutics. These technologies should enable rapid identification and engineering of phages targeting bacterial pathogens for use in clinical settings. Approaches include, but are not limited to, phage genome engineering, phage bioinformatics, high-throughput screening platforms, assistive devices for engineering/purification, and deep learning.
Development of technologies targeting mitochondrial DNA. These technologies should enable modifications to or replacement of mitochondrial DNA in the context of human disease and disease mechanisms.
Deployment of genomic technologies to interrogate the noncoding genome. This includes the use of precise editing technologies, deep learning, high throughput proteomics, and other emerging technologies to understand the functional ramifications of non-protein-coding sequences in the human genome.
Considering applicants on an ongoing basis.
To apply, send a cover letter and CV to seth.shipman@gladstone.ucsf.edu. Cover letter should identify a project area or specific idea that you hope to pursue.
Qualifications
PhD degree in Biochemistry, Bioengineering, Chemical Engineering or related field
Excellent teamwork, organizational, communication, and time-management skills, demonstrated by publications and references
Prior experience in biotechnology, molecular biology, cell biology, biochemistry, microbiology, or bioinformatics with a strong desire to make an impact on human disease via molecular technology
Undergraduate Researchers (Summer)
We welcome undergraduates into the lab to gain experience in research each summer. Interested students can apply to PUMAS (Promoting Underrepresented Minority Advancement in the Sciences) or UCSF STRP (Summer Research Training Program) directly.